SEOUL NATIONAL UNIVERSITY
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신동미사진
  • 성명 신동미
  • 직위 부교수
  • 학과 식품영양학과
  • 전공 영양생리학, 영양유전체학, 시스템영양학
  • 사무실 생활과학대학 222동 611호
  • 홈페이지
  • 이메일 shindm@snu.ac.kr
  • 연락처 02-880-6832

연구영역

  • 비타민이 신경세포 분화에 미치는 영향
  • 암 발생에 영향을 미치는 세포 내 신호전달 연구
  • B 세포의 정상 분화와 림포마에 관한 연구
  • 생물정보학을 이용한 영양유전체학 연구

학력

  • 1996서울대학교 농가정학과 (학사)
  • 1999 서울대학교 식품영양학과 (석사)
  • 2005 서울대학교 식품영양학과 (박사)

경력

  • 2012.8 – 현재 서울대학교 식품영양학과 부교수
  • 2011.1 – 2012.7 미국 NIH Staff Scientist
  • 2006.1 – 2010.12 미국 NIH Postdoctoral fellow
  • 2001.11 – 2005.12 한양대학교 의생명공학원 연구원
  • 2005.9 – 2005.12 한양대학교 시간강사
  • 2005.3 – 2005.8 가톨릭대학교 시간강사
  • 2001.3 – 2005.12 단국대학교 시간강사

저서

  • 구재옥, 김정희, 곽호경, 신동미 저. 생활주기영양학, 한국방송통신대학교출판부, 2013년 1월 발행, ISBN 978-89-20-01014-9
  • Morse, H.C. III, Janz, S., Qi, C.-F., Shin, D.-M., Davidson, W.F., Wang, H., Li, Z., Roopenian, D.C., Hartley, J.W., Fredrickson, T.N., Kovalchuk, A., and Potter, M. “Features of plasma cell-related neoplasms in mice,” NIAID Intramural Research book. (in press)

연구논문

  • Qi CF, Zhang R, Sun J, Li Z, Shin DM, Wang H, Kovalchuk AL, Sakai T, Xiong H, Kon N, Gu W, Morse HC 3rd.HomeostaticdefectsinBcellsdeficientintheE3ubiquitinligaseARF-BP1arerestoredbyenhancedexpressionofMYC.Leuk Res. 37(12):1680-9, 2013
  • Choi SC, Wang H, Tian L, Murakami Y, Shin DM, Borrego F, Morse HC 3rd, Coligan JE. Mouse IgM Fc Receptor, FCMR, Promotes B Cell Development and Modulates Antigen-Driven Immune Responses. J Immunol. 190(3):987-96, 2013
  • Wang H, Shin DM, Abbasi S, Jain S, Kovalchuk AL, Beaty N, Chen S, Gonzalez-Garcia I, Morse HC 3rd. Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions. Proc Natl Acad Sci U S A. 109(49):20077-82, 2012
  • Wang, H., Beaty, N., Chen, S., Qi, C.-F., Masiuk, M., Shin, D.-M. and Morse, H.C. III. The CXCR7 chemokine receptor promotes B cell retention in the splenic marginal zone and serves as a sink for CXCL.12. Blood 119(2):465-8, 2012
  • Shin, D.M, Lee, C.H., Morse, H.C. IRF8 governs expression of genes involved in innate and adaptive immunity in human and mouse germinal center B cells. PloS One. 6(11):e27384 2011
  • McPhee, C.G. ,Sproule, T.J., Shin, D.-M., Bubier, J. G., Schott, W.H, Avenesyan, L., Steinbuck, M., Morse, H.C. III, Roopenian, D.C. MHC Class I Family Proteins Retard SLE Autoimmunity and B Cell Lymphomagenesis. J Immunol. 187(9):4695-704 2011
  • Keszei, M., Detre, C., Rietdijk, S.T., Mu?oz, P., Romero, X., Berger, S.B., Calpe, S., Liao, G., Castro, W., Julien, A., Wu, Y.-Y., Shin, D.-M., Sancho, J., Zubiaur, M., Morse, H.C. III, Morel, L., Engel, P., Wang, N. and Terhorst, C. A novel isoform of the murine lupus susceptibility gene Ly108 ameliorates disease. J. Exp. Med. 2011 March 21. [Epub ahead of print]
  • Abbasi S, Shin DM, Beaty N, Masiuk M, Chen S, Gonzalez-Garcia I, Zhao M, Goding J, Morse HC 3rd, Wang H. Hybridoma (Larchmt). Characterization of monoclonal antibodies to the plasma cell alloantigen ENPP1. 30(1):11-7, 2011
  • Feng J, Wang H, Shin DM, Masiuk M, Qi CF, Morse HC 3rd. J Immunol. IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools.186(3):1458-66, 2011
  • Miletic, A.V., Anzelon-Mills, A., Mills, D.M., Omori, S.A., Pedersen, Shin, D.-M., Ravetch, J.V., Bolland, S., Morse, H.C. III and Rickert, R.C. Coordinate suppression of B Cell lymphoma by PTEN and SHIP phosphatases. J. Exp. Med. 207 (11):2407-20, 2010.
  • Peled J.U., Sellers R.S., Iglesias-Ussel M.D., Shin D.M., Montagna C., Chunfang Zhao C., Li Z., Edelmann W., Morse H.C. III, Scharff M.D. Msh6 protects mature B cells from lymphoma by preserving genomic stability. Amer. J. Pathol, 177(5), 2597-2608, 2010
  • Li Z., Qi C.F., Shin D.M., Zingone A. Newbery H.J., Kovalchuk A.L., Abbott C.M., and Morse H.C. III. Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas. PLoS One. 5(5):e10755, 2010
  • Zingone A., Cultraro C.M., Shin D.M., Bean C.M., Morse H.C. III, Janz S. and Kuehl W.M. Ectopic expression of wild-type FGFR3 cooperates with MYC to accelerate development of B cell lineage neoplasms. Leukemia. (6):1171-78, 2010
  • Suzuki T, Kosaka-Suzuki N, Shin DM, Yoon JH, Abdullaev Z, Pugacheva E, Pack S, Morse HC III, Loukinov D, Lobanenkov V. Expression of a testis-specific form of Gal3st1(CST), a gene essential for spermatogenesis, is regulated by the CTCF paralogous gene, BORIS. Mol Cell Biol. 30(10):2473-84, 2010
  • Shin D.M., Qi C.F., Li Z, Wang H, Feng J, Hartley JW, Fredrickson TN, Kovalchuk A, Morse HC III. Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice. J Pathol. 221(1):106-16, 2010 (Co-first author)
  • Rutsch S., Neppalli V.T., Shin D.M., Dubois W., Morse H.C III, Goldschmidt H, Janz S. IL-6 and MYC collaborate in plasma cell tumor formation in mice. Blood. 115(9):1746-54, 2010
  • Li Z., Wang H., Xue L., Shin D.M., Roopenian D., Xu W., Qi C.F., Sangster M.Y., Orihuela C.J., Tuomanen E., Rehg J.E., Cui X., Zhang Q., Morse H.C. III, Morris S.W.. Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma. Blood. 114(19):4158-68, 2009
  • Ozato, K., Shin, D.M., Chang, T.-H. and Morse, H.C. III TRIM family proteins and their emerging roles in innate immunity. Nature Rev. Immun., 8:849-860, 2008
  • Shin, D.M., Shaffer, D.J., Wang, H., Roopenian, D.C. and Morse, H.C. III NOTCH is part of the transcriptional network regulating cell growth and survival in mouse plasmacytomas. Cancer Res. 68(22):9202-11, 2008
  • Yu, D., Cook, M.C., Shin, D.M., Silva, D.G., Marshall, J., Toellner, K.M., Havran, W.L., Caroni, P., Cooke, M.P., Morse, H.C. III, Maclennan, I.C., Goodnow, C.C. and Vinuesa, C.G. Axon growth and guidance genes identify T-dependent germinal centre B cells. Immunol Cell Biol., 86(1):3-14, 2007
  • Koo, J.O., Kim, S.K. and Shin, D.M. Biochemical nutritional status of serum lipids, protein, and blood glucose in school children in Bucheon. J Community Nutrition 7(1):3-7, 2005
  • Chung, H., Hong, D.P., Kim, H.J., Jang, K.S., Shin, D.M., Ahn, J.I., Lee, Y.S., and Kong, G. Differential gene expression profiles in the steatosis/fibrosis model of rat liver by chronic administration of carbon tetrachloride. Toxicology and Applied Pharmacology 208(3):242-254, 2005
  • Ahn, J.I., Lee .K.H., Shin, D.M., Shim, J.W., Lee, J.S., Chang, S.Y., Lee, Y.S., Brownstein, M.J., Lee, S.H. and Lee Y.S Comprehensive transcriptome analysis of differentiation of embryonic stem cells into midbrain and hindbrain neurons. Develop. Biol., 265(2):491-501, 2004
  • Ahn, J.I., Lee, K.H., Shin, D.M., Shim, J.W., Kim, C.M., Kim, H., Lee, S.H. and Lee, Y.S. Temporal expression changes during differentiation of neural stem cells derived from mouse embryonic stem cell. J. Cell. Biochem., 93(3):563-578, 2004.
  • Shin, D.M., Ahn, J.I., Lee, K.H. and Lee, Y.S and Lee, Y.S. Ascorbic acid responsive genes during neuronal differentiation of embryonic stem cells. Neuroreport, 15(12):1959-63, 2004
  • Yu, D.H., Lee, K.H., Lee, J.Y., Kim, S., Shin, D.M., Kim, J., Lee, Y.S., Oh, S.K., Moon, S.Y., Lee, S.H. and Lee, Y.S. Changes of gene expression profiles during neuronal differentiation of central nervous system precursors treated with ascorbic acid. Journal of Neuroscience Research, 78(1):29-37, 2004
  • Kim, J.H., Shin, D.M. and Lee, Y.S.. Effect of local background intensities in the normalization of cDNA microarray data with a skewed expression profiles. Experimental and Molecular Medicine, 34(3):224-232, 2002
  • Shin, D.M. and Lee, Y.S. Effects of dietary calcium and sodium levels on lipid metabolism in hyperlipidemic/hypercholesterolemic rats. The Korean Journal of Nutrition, 33(4):403-410, 2000.

학술대회발표 및 초청강연

  • Shin, DM., Lee, YS. Effects of Dietary Calcium and Sodium Levels on Lipid Metabolism in Hypercholesterolemia/Hyperlipid-emia Model Rats, 6th Asia/Oceania Regional Congress of Gerontology, Seoul, Korea, 1999
  • Shin, DM., Lee, YS. Effects of dietary Ca and Na levels on blood pressure and lipid profile in hyperlipidemic rats with or without hypertention, FASEB Experimental Biology Conference, Orlando, U.S.A, 2001
  • Shin, DM., Kim, JH., Lee, YS. A new normalization method for cDNA microarray data using clustering background, 10th International Conference on Intelligent Systems for Molecular Biology (ISMB), Edmonton, Canada, 2002
  • Shin, DM., Ahn JI., Lee, KH., Lee, YS. Expression profiling and analysis of transcription facotrs for neuronal differentiation from stem cells, 11th International Conference on Intelligent Systems for Molecular Biology (ISMB), Brisbane, Australia, 2003
  • Shin, DM., Shaffer D., Roopenian D., Morse, HC. Mouse B cell lineage neoplasms:comparative analyses of gene expression using high throughput real time RT-PCR and oligonucleotide microarray, The American society of hematology, Orlando, U.S.A, 2006
  • Li, Z., Xue, L., Shin, D.M., Qi, CF., Zhang, Q., Xu, W., Morris, S.W., Morse, H.C., Wang, H. Constitutive activation of the canonical NF- B signaling pathway and expanded populations of splenic marginal zone B cells characterize E -BCL10 transgenic mice. 49th Annual Meeting of American Society of Hematology, Atlanta, Georgia, 2007.
  • Wang, H., Beaty, N., Shin, D.M., Feng, J., Chen, S., and Morse, H.C.III. Identification of plasma cell antigen PC-1 as a novel cell surface marker of germinal center, memory and plasmacytoma B cells. 50th Annual Meeting of American Society of Hematology, San Francisco, California, 2008.
  • Shin, D.M., Wang, H., Qi, C.F., Schutte, B.C., Morse, H.C. III. Interferon regulatory factor 6 (IRF6) influences late B cell differentiation. Keystone Symposia – B cells in context. Taos, New Mexico. 2009.
  • Shin, D.M., Lee, C.H., Morse, H.C. III. Transcriptional Network Governed by Interferon Regulatory Factor 8 (IRF8) in Germinal Center B cells. 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB). Boston, MA, 2010.
  • Shin, D.M. Transcriptional Network Governed by Interferon Regulatory Factor 8 in Germinal Center B cells. Lecture in Immunology and hematology interest group of Jackson laboratory, Bar harbor, ME, 2010.

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