연구실
연구영역
- 생애 주기 및 질환 상태에 따른 식이-마이크로바이옴-인체 간 상호작용 규명
• Research Area: Host-microbes interactions, foods/diet-microbiome interactions, human andmicrobial physiology, microbiome and nutrition through the life cycle
• Target Diseases: Metabolic diseases (obesity, T2D, NAFLD): Gut-liver axis, Asthma:Gut-lung axis, Autism Spectrum Disorder: Gut-brain axis, Atopic Dermatitis:Gut-skin axis
• Tools &Methodology: Multi-omics analysis (shotgun/WGS, metagenome, metabolome, pathway profile analysis
학력
- 서울대학교 식품영양학과 (학사)
- 서울대학교 식품영양학과 (석사)
- 서울대학교 식품영양학과 (박사)
경력
- 서울대학교 보건환경연구소
- 서울대학교 생명공학공동연구원
- ㈜고바이오랩 마이크로바이옴 센터장
연구논문
- Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation, 202304, 11.15, BMC Medicine
- Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease, 202301, 12.17, Experimental and Molecular Medicine
- Bacteroides vulgatus SNUG 40005 Restores Akkermansia Depletion by Metabolite Modulation, 202301, 33.88, Gastroenterology
- Distinct Changes in Microbiota-Mediated Intestinal Metabolites and Immune Responses Induced by Different Antibiotics, 202212, 5.22, Antibiotics
- Wnt-activating human skin organoid model of atopic dermatitis induced by Staphylococcus aureus and its protective effects by Cutibacterium acnes, 202209, 6.11, iScience
- Interaction effect between NAFLD severity and high carbohydrate diet on gut microbiome alteration and hepatic de novo lipogenesis, 202205, 9.43, Gut Microbes
- Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium, 202205, 9.43, Gut Microbes
- Sputum Bacterial Metacommunities in Distinguishing Heterogeneity in Respiratory Health and Disease, 202203, 6.06, Frontiers in Microbiology
- Butyl-fructooligosaccharides modulate gut microbiota in healthy mice and ameliorate ulcerative colitis in a DSS-induced model, 202202, 6.32, Food and Function
- Therapeutic Potential of a Novel Bifidobacterium Identified Through Microbiome Profiling of RA Patients With Different RF Levels, 202111, 8.79, Frontiers in Immunology
- Gut microbiome signatures distinguish type 2 diabetes mellitus from non-alcoholic fatty liver disease, 202110, 6.16, Computational and Structural Biotechnology Journal
- In vitro and in vivo inhibition of Helicobacter pylori by Lactobacillus plantarum pH3A, monolaurin, and grapefruit seed extract, 202111, 6.32, Food and Function
- Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice, 202104, 30.96, Nature Microbiology
- Protective Effects of Korean Herbal Remedy against Airway Inflammation in an Allergic Asthma by Suppressing Eosinophil Recruitment and Infiltration in Lung, 202012, 7.68, Antioxidants
- Effects of selenium- and zinc-enriched Lactobacillus plantarum SeZi on antioxidantand microbial selenocompounds metabolism in an ICR mouse model, 202010, 7.68, Antioxidants
- Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD, 202010, 17.694, Nature Communications
- Co-Culture with잹ifidobacterium catenulatum쟅mproves the Growth, Gut Colonization, and Butyrate Production of쟂aecalibacterium prausnitzii: In Vitro and In Vivo Studies., 202005, 4.926, Microorganisms
- Production, Structural Characterization, and In Vitro Assessment of the Prebiotic Potential of Butyl-Fructooligosaccharides, 202001, 6.208, International Journal of Molecular Sciences
- Vaginal lactobacilli inhibit growth and hyphae formation of Candida albicans, 201905, 4.997, Scientific Reports
- Gut Microbial Composition and Function Are Altered in Patients with Early Rheumatoid Arthritis, 201905, 4.964, Journal of Clinical Medicine
- The Anti-Rotaviral Activity of Low Molecular Weight and Non-Proteinaceous Substance from잹ifidobacterium longum잹ORI Cell Extract. , 201904, 4.926, Microorganisms
- Biocatalysis of Platycoside E and Platycodin D3 Using Fungal Extracellular β-Glucosidase Responsible for Rapid Platycodin D Production., 201809, 6.208, International Journal of Molecular Sciences
- Bile salt hydrolase-mediated inhibitory effect of Bacteroides ovatus on growth of Clostridium difficile, 201711, 2.902, Journal of Microbiology
- Inactivation of Norovirus by Lemongrass Essential Oil Using a Norovirus Surrogate System, 201708, 2.753, Journal of Food Protection
- The effect of heritability and host genetics on the gut microbiota and metabolic syndrome, 201706, 31.795, Gut
- Prevotella as a Hub for Vaginal Microbiota under the Influence of Host Genetics and Their Association with Obesity, 201701, 31.316, Cell Host & Microbe
- Curcumin shows antiviral properties against norovirus, 201610, 4.927, Molecules
- Review on Bifidobacterium bifidum BGN4: Functionality and nutraceutical applications as a probiotics microorganism, 201609, 6.208, International Journal of Molecular Sciences
- Whole-cell biocatalysis for producing ginsenoside Rd from Rb1 using Lactobacillus rhamnosus GG, 201607, 3.277, Journal of Microbiology and Biotechnology
- Effects of ascorbic acid on α-l-arabinofuranosidase and α-l-arabinopyranosidase activities from Bifidobacterium longum RD47 and its application to whole cell bioconversion of ginsenoside, 201508, Journal of the Korean Society for Applied Biological Chemisty
- Inactivation of norovirus and surrogates by natural phytochemicals and bioactive substances, 201501, 6.575, Molecular Nutrition and Food Research
- High Expression of β-Glucosidase in Bifidobacterium bifidum BGN4 and Application in Conversion of Isoflavone Glucosides During Fermentation of Soy Milk, 201504, 3.277, Journal of Microbiology and Biotechnology
- Changes in growth and survival of Bifidobacterium by coculture with Propionibacterium in soy milk, cow’s milk, and modified MRS medium, 201206, 5.911, Internationa Journal of Food Microbiology
- Enhancement of the tyrosinase inhibitory activity of Mori Cortex Radicis extract by biotransformation using Leuconostoc paramesenteroides PR, 201205, 2.337, Bioscience, Biotechnology, and Biochemistry
- Ginsenoside metabolite compound K differentially antagonizing tumor necrosis factor-α-induced monocyte-endothelial trafficking, 201110, 5.168, Chemico-Biological Interactions
- Transformation of rutin to antiproliferative quercetin-3-glucoside by Aspergillus niger, 201010, 5.895, Journal of Agricultural and Food Chemistry
담당교과목
- 학부: 인체생리학, 생애주기영양학
주요연구내용 및 연구과제
- 대규모 한국인 비알코올지방간 전향 코호트에서 간병리 조직 소견에 따른 분변 내 마이크로비옴 분석 (2021년, 보건복지부보건의료 R&D 100대 우수연구성과 선정)
- 마이크로비옴 조절을 통한 천연물 유래 만성 호흡기 질환 치료제 개발
- 마이크로바이옴 네트워크 분석과 한국인 유래 분리 균주를 활용한 대사항상성 유지 장내 미생물 컨소시아 연구
- 마이크로바이옴 유래 대사성질환 제어 신소재 발굴 및 생산 플랫폼 구축
- 세로토닌과 T도움 17세포 이중 조절 휴먼 마이크로바이옴을 통한 자폐스펙트럼 장애 중증도 개선
- 삼제 병용 마이크로바이옴 균주 복합체를 이용한 경구용 비만 치료제 개발
